Basic Information
VIS ID
TVIS44017145
Fusion event
HTLV-1-chr10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
123217386/121457872 (Hg38)
End
123217386/121457872 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1499280; hsa-mir-202/Downstream/959093;
Nearest TSS
ENST00000439456/Upstream/279172; ENST00000447943/Downstream/22613;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/477994, chr10-CpG: 185/Downstream/139230
Nearby gene
FGFR2(-20458) ;
Nearest cancer related gene
FGFR2(OG, -20458) ;
Upstream sequence
CTGCAGACTCGTCACCAGTAACCCAGCTCCCAGCAACCCCCCAAAGGGGAAGCAAAAAGAAATAGGGTCTGACCTGAGACCTCAGCATATACCTGCACAC
Downstream sequence
ACATACAGATGCAAGAGCTTGGGTCCACCTGAAACCAGAGAGGGAAACTGGCACCTGCCCAAGTCCCTGCAGCAAACCCTTCGCCTGCAGCCTGTTTCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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