Basic Information
VIS ID
TVIS44017157
Fusion event
HTLV-1-GLRX3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
131956913/130158649 (Hg38)
End
131956913/130158649 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
GLRX3
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-1226-3p ; hsa-mir-2114-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-3065-3p ; hsa-mir-4267 ; hsa-mir-4286 ; hsa-mir-6778-3p ; hsa-mir-6823-3p
Nearest miRNA
hsa-mir-107/Upstream/315275; hsa-mir-202/Downstream/803939;
Nearest TSS
ENST00000439456/Upstream/22250; ENST00000486974/Downstream/1097;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/21589, chr10-CpG: 116/Downstream/31298
Upstream sequence
TGATCCTTGCTGaatgcccagtgcgtagtgggcactccatagatgttagttgaaagaCAGAAAATAATGAGCTGGAGGATGGTAGTGTAGGCATGCCCTA
Downstream sequence
GTCATTAACTTTTCTGGTCATCTTTGATCTGAGTGTGCTGTTGTGTATGTGAAAGAAAATAACACAAACGTCTTTAAAACTTTTGAGAGTCTGTTCTAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate