Basic Information
VIS ID
TVIS44017161
Fusion event
HTLV-1-ECHS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135184330/133370826 (Hg38)
End
135184330/133370826 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ECHS1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-186-5p ; hsa-mir-152-3p ; hsa-mir-15b-5p ; hsa-mir-548a-3p
Nearest miRNA
hsa-mir-107/Upstream/123206; hsa-mir-3944/Downstream/730;
Nearest TSS
ENST00000439456/Upstream/12791; ENST00000528127/Downstream/2863;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/12376, chr10-CpG: 87/Downstream/2012
Nearest cancer related gene
ECHS1(OG, No orient, 0)
Upstream sequence
TTTTCTGCGATGATGTACTCAAAGTTAGCACCTGGAGCAAGAAGGCAAAAAGGGGTATCTATTCACACAGGTATCAAACTGGGGAGAGTGGGGGAAGGGA
Downstream sequence
TGTGGCCCCATCGGTGGATACAGTGTGACCCCAAGAGGCCCTCTGAGGGCTCCCTGCCGAGTCCTCAGTGGCTCCAGGTGTAGCTCTCAGCCACAAGGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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