Basic Information
VIS ID
TVIS44017164
Fusion event
HTLV-1-FAM107B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
14645315/14603316 (Hg38)
End
14645315/14603316 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM107B
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-3942-3p ; hsa-mir-759 ; hsa-mir-5197-3p ; hsa-mir-6882-5p ; hsa-mir-6507-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-6507-5p ; hsa-mir-8485 ; hsa-mir-1183 ; hsa-mir-3607-3p ; hsa-mir-4311
Nearest miRNA
hsa-mir-1265/Upstream/166655; hsa-mir-107/Downstream/3241791;
Nearest TSS
ENST00000439456/Upstream/30977; ENST00000443282/Downstream/954;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/711132, chr10-CpG: 135/Downstream/437
Upstream sequence
GTAGCCCAGACACTATTTCAACTTAAAGCCACTTGGATAGATAGAATTTCCAAAGTGATGTTAGGAAAACGTGGCTGGAGGAGAAAACCGATGTACTTGA
Downstream sequence
TAGCAAGAAATCGCAAGTTTAAGAATGTGAAGTCCAACAGCCCTCATTCCGTTTTTCTTTGACCCCTCAAAATCGCACCCATCCTATCAAGTAACTTTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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