Basic Information
VIS ID
TVIS44017194
Fusion event
HTLV-1-CXCL12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
44844288/44348840 (Hg38)
End
44844288/44348840 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
CXCL12
miRNAs that regulate target gene
hsa-mir-23a-3p ; hsa-mir-31-5p ; hsa-mir-886-3p ; hsa-mir-126-5p ; hsa-mir-126-3p ; hsa-mir-146a-5p ; hsa-mir-7152-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6765-3p ; hsa-mir-1228-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-221-3p ; hsa-mir-454-3p ; hsa-mir-137 ; hsa-mir-1-5p ; hsa-mir-1-3p ; hsa-mir-448
Nearest miRNA
hsa-mir-1265/Upstream/1351159; hsa-mir-107/Downstream/815174;
Nearest TSS
ENST00000439456/Upstream/55131; ENST00000460364/Downstream/36203;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/37559, chr10-CpG: 213/Downstream/35426
Nearby gene
CXCL12(-21313) ;
Nearest cancer related gene
CXCL12(TSG, No orient, 0)
Upstream sequence
TCCAGTCTCAGAACTTTCCCCATCAAGAAGACAGGTCTAGGGGACAAGAGGCTGTGCTGTTCTCAAACCCAGAAAGGCCCTCCAGCACACCATGGAAGAC
Downstream sequence
CAAGCTGACATTCACTACTTACCCTTCATTCGATACATGCATCACGTCCTGGCATGATCCTACGTAGTCACTGTTTCCTTTCTGCATGCACCGCTTGGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate