Basic Information
VIS ID
TVIS44017196
Fusion event
HTLV-1-GPRIN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
46993963/46555652 (Hg38)
End
46993963/46555652 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
GPRIN2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-337-3p ; hsa-mir-6715b-3p ; hsa-mir-190a-3p ; hsa-mir-4267 ; hsa-mir-488-5p ; hsa-mir-10b-3p ; hsa-mir-5586-5p ; hsa-mir-5011-5p ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-5189-3p ; hsa-mir-4301 ; hsa-mir-433-5p ; hsa-mir-140-3p ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-148b-5p ; hsa-mir-3692-5p ; hsa-mir-4251 ; hsa-mir-4277 ; hsa-mir-4663 ; hsa-mir-4701-5p ; hsa-mir-588 ; hsa-mir-589-5p ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-6874-3p ; hsa-mir-7153-5p ; hsa-mir-7160-5p ; hsa-mir-8077 ; hsa-mir-93-3p
Nearest miRNA
hsa-mir-1265/Upstream/1391564; hsa-mir-107/Downstream/2429860;
Nearest TSS
ENST00000439456/Upstream/122; ENST00000512997/Downstream/22565;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/14120, chr10-CpG: 88/Downstream/669
Upstream sequence
GTGCCCCCCAGGGATTGTGGGCAAATCCTCCCCAGGGGAGGAAGCTCAGGGGCTGTTGGGCGCCTAGGCCTCTTCCTGGTGAGCAGAGCCTCATCCATGG
Downstream sequence
GGCCACTGACCCCACAGTTACCCCAGAACCCTTTCCTGGCACAGCTTGTGACCCGGGGCATGTAGCCCTTAAGGCACGTTCATTGTGAAGGGCAGGTTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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