Basic Information
VIS ID
TVIS44017198
Fusion event
HTLV-1-ZNF488 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
48373071/47366289 (Hg38)
End
48373071/47366289 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA10G
Target gene
ZNF488
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-6882-3p ; hsa-mir-4480 ; hsa-mir-6854-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-642a-5p ; hsa-mir-6742-5p ; hsa-mir-7704 ; hsa-mir-615-5p ; hsa-mir-2861 ; hsa-mir-7106-3p ; hsa-mir-6845-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4469 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-1265/Upstream/2202201; hsa-mir-107/Downstream/1619223;
Nearest TSS
ENST00000439456/Upstream/17918; ENST00000434533/Downstream/17972;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/15947, chr10-CpG: 19/Downstream/2208
Upstream sequence
gttccaggcagcagcactcccacctggctgctctgatgtcctcgctccctccattcctgcctctcaccatgcacgcatccattgtccacacacacacaac
Downstream sequence
cagataatcttctgaaagtgtaactcagatgatgcctccaaccctgtggctgcccttcacacttacaggcctaaccccagcaggacctgccagctgcttc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate