Basic Information
VIS ID
TVIS44017210
Fusion event
HTLV-1-BICC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
60400332/58640572 (Hg38)
End
60400332/58640572 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
BICC1
miRNAs that regulate target gene
hsa-mir-3912-5p ; hsa-mir-4716-5p ; hsa-mir-6834-3p ; hsa-mir-3668 ; hsa-mir-129-5p ; hsa-mir-4776-3p ; hsa-mir-6875-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-4778-3p ; hsa-mir-942-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-4511 ; hsa-mir-548b-3p
Nearest miRNA
hsa-mir-1265/Upstream/1336013; hsa-mir-107/Downstream/4732385;
Nearest TSS
ENST00000439456/Upstream/19723; ENST00000263103/Downstream/152963;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/126876, chr10-CpG: 121/Downstream/535495
Upstream sequence
TAAATTATGGACTGCCCTTCTTCCCTTTGTGACCTCTTAAATCTCTGAGACCAAAAATATTTACATATGCAGCTTATAGACATTTGTTAAACCCTAAGAT
Downstream sequence
GGTTATTGCAGCCATGGGATACTCAATTAACTGTGcatttactcaccaaaaattgtttttgagcccactagtgtgtggcaggtactgagttgggcctttg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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