Basic Information
VIS ID
TVIS44017212
Fusion event
HTLV-1-ZNF365 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
64424387/62664627 (Hg38)
End
64424387/62664627 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
ZNF365
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-7-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-1265/Upstream/5360068; hsa-mir-107/Downstream/708330;
Nearest TSS
ENST00000439456/Upstream/20756; ENST00000373783/Downstream/140230;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/289966, chr10-CpG: 152/Downstream/140048
Upstream sequence
GAATTCCATGACTGGGCAGCATGAACAGAAATAGGGAAGCCAGGGCTGGGGTGTGGAAAGAGAAAAGAGGCTGTGTTCCACATGGAGAGTCACTGAGGAG
Downstream sequence
CCCTGAAGGCACAGGCAAGAGATGAGGGCAGAGGAAAGATCGGGGGTAACCTCCAGAGAAGGGCAGACTGAACTCGGAAAATGCCTGAATATAGGGAGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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