Basic Information
VIS ID
TVIS44017219
Fusion event
HTLV-1-COL13A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
71602887/69843131 (Hg38)
End
71602887/69843131 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
COL13A1
miRNAs that regulate target gene
hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-744-3p ; hsa-mir-6794-3p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-3944-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-4746-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-1304-3p ; hsa-mir-4639-3p ; hsa-mir-1182 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-3664-5p ; hsa-mir-3714 ; hsa-mir-3910
Nearest miRNA
hsa-mir-1265/Upstream/2439721; hsa-mir-107/Downstream/1947616;
Nearest TSS
ENST00000439456/Upstream/40707; ENST00000484990/Downstream/34165;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/40011, chr10-CpG: 147/Downstream/209431
Upstream sequence
GCCTAAAGGCCTTCTGCAAAGAaatcatggctcctaggctgtcagtgctggagggtgggggttatctcttccagcacccacgtcacagcaggagaggggg
Downstream sequence
cccagagaggtgagatTCTCACCATGTCGTGTTGCTCAAGTGGTCAGAAGATTCAGCCTCCACGTGGAGGCCATCGGCCCACATGATAGCTGGTGTGATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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