Basic Information
VIS ID
TVIS44017224
Fusion event
HTLV-1-USP54 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
75366932/73607174 (Hg38)
End
75366932/73607174 (Hg38)
Orient
-
Location type
Intronic
Target gene
USP54
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-1303 ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1265/Upstream/886074; hsa-mir-107/Downstream/1945284;
Nearest TSS
ENST00000439456/Upstream/15634; ENST00000595595/Downstream/18476;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/111357, chr10-CpG: 67/Downstream/18150
Nearby gene
MYOZ1(-24438) ;
Upstream sequence
caaggtaggaggatagcttgagcccaggagtttgagaccagcctgggcaacatggtgaaaccccatcactacaaaaaatacaaaaattagccaggtgtgg
Downstream sequence
tggcatgcacctgtagtcccaactactcaggaggatcacttgagtccaggaggtggaggctgcagtgagccataatcctgccattgcactccatcttgca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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