Basic Information
VIS ID
TVIS44017227
Fusion event
HTLV-1-ADK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
75944114/74184356 (Hg38)
End
75944114/74184356 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADK
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-5571-5p ; hsa-mir-4674 ; hsa-mir-6878-3p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-4437 ; hsa-mir-4757-5p ; hsa-mir-6744-3p ; hsa-mir-378g ; hsa-mir-4680-5p ; hsa-mir-532-3p ; hsa-mir-212-5p ; hsa-mir-6513-3p ; hsa-mir-1224-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-6813-3p ; hsa-mir-498 ; hsa-mir-592 ; hsa-mir-4279 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-597-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1914-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-1265/Upstream/1463256; hsa-mir-107/Downstream/1368102;
Nearest TSS
ENST00000439456/Upstream/7670; ENST00000467840/Downstream/341008;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/7126, chr10-CpG: 35/Downstream/629081
Upstream sequence
Caggatgaccatatgttccagtttgcccaggacaattctggatcatgcctgttatcctgacattattatttattattattttttcttttgtagacacagg
Downstream sequence
gtcttgctctgctgcccagctggagtgcagtagtgcaatcatggctcactgtaaccttgaaatcctgggctcaagtgatcctcccacctcagccctccag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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