Basic Information
VIS ID
TVIS44017228
Fusion event
HTLV-1-KAT6B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
76691732/74931974 (Hg38)
End
76691732/74931974 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
KAT6B
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-1236-3p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4795-5p ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-6831-3p ; hsa-mir-4311 ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-1265/Upstream/2210874; hsa-mir-107/Downstream/620484;
Nearest TSS
ENST00000439456/Upstream/93274; ENST00000490365/Downstream/44547;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/104896, chr10-CpG: 37/Downstream/111808
Upstream sequence
ctaatttttgtatttttagtagagacagagttttgccatgttggccaggctggtctcaaactcccgatctcaagtaatcctcctgtgttggcctcccaaa
Downstream sequence
gtgctgggattacaggcgtgagccaccacgcccggcTGAAAGCATGTTCTTGAATGTATATGTGTGTTCTCTCCCCATGTGATTTGTAAACCCTCCAAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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