Basic Information
VIS ID
TVIS44017239
Fusion event
HTLV-1-chr10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.31
Reference genome
GRCh37/hg19
Start
89953274/88193517 (Hg38)
End
89953274/88193517 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
LOC101929727 ; RNLS
miRNAs that regulate target gene
hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-4708-3p ; hsa-mir-892c-5p ; hsa-mir-9500 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5584-5p ; hsa-mir-4735-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-548n
Nearest miRNA
hsa-mir-1265/Upstream/689563; hsa-mir-107/Downstream/869818;
Nearest TSS
ENST00000439456/Upstream/241318; ENST00000526923/Downstream/389673;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/329189, chr10-CpG: 61/Downstream/389254
Nearby gene
RNLS(-80347) ;
Upstream sequence
ATTTCACTTCTCTCCCTCACATACCAATGAAACCTTCCTCTTCACTCATCTGGGACCACTATCCCCACCCCACCACCACCCTGTACATTTCTGCCTCTGA
Downstream sequence
ATCTTTGCTTGAATAACTTTGTTTCCATGTCTTCTGTCAAAATCATACGTATTTTTTAAGAGCAAACTCAAGAAATATCACATATGCTTCCCTGATCCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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