Basic Information
VIS ID
TVIS44017250
Fusion event
HTLV-1-ARHGAP19-SLIT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
98939826/97180069 (Hg38)
End
98939826/97180069 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ARHGAP19-SLIT1
miRNAs that regulate target gene
hsa-mir-211-3p ; hsa-mir-214-3p ; hsa-mir-3619-5p ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-4530 ; hsa-mir-617 ; hsa-mir-6510-5p ; hsa-mir-6858-3p ; hsa-mir-761
Nearest miRNA
hsa-mir-107/Upstream/351305; hsa-mir-1287/Downstream/695744;
Nearest TSS
ENST00000439456/Upstream/24636; ENST00000490980/Downstream/5554;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/136392, chr10-CpG: 108/Downstream/5236
Upstream sequence
ACTCCGCCAAGCACCCGTCTGCTCCCAATAATGCAGGAGCCGCCCAGCCCCAAAAGAGCACGGCCGCCCCTGCTGGCAGCCTCGGGCAGCCTGGGCCACC
Downstream sequence
GACAGCCCGCCCCGCCCAAGAAGGGGCACCGAGGAAGATCAGCCCCTCCCCTTGTGCTCCAGGGTTCCCAGCGGCTGCCTGATGGCGAAGAGGAGGGCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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