Basic Information
VIS ID
TVIS44017255
Fusion event
HTLV-1-ARHGAP42 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100850599/100979868 (Hg38)
End
100850599/100979868 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGAP42
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-28-5p ; hsa-mir-222-3p ; hsa-mir-138-5p ; hsa-mir-376c-3p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-4299 ; hsa-mir-3692-5p ; hsa-mir-4633-3p ; hsa-mir-6071 ; hsa-mir-6500-5p ; hsa-mir-587 ; hsa-mir-6131 ; hsa-mir-3185 ; hsa-mir-133a-5p ; hsa-mir-93-3p ; hsa-mir-885-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-4511
Nearest miRNA
hsa-mir-10392/Upstream/4638342; hsa-let-7a-2/Downstream/539952;
Nearest TSS
ENST00000527297/Upstream/20018; ENST00000303130/Downstream/12212;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/292198, chr11-CpG: 170/Downstream/147431
Upstream sequence
TATAAATGTGAGAACTTGAATAACAAACCTTGATTTTTCCTTTAGATGTACGAACACATTTTTGAGCATCCAATGTCTGGCTAATTGAGGCTGTGAAGGA
Downstream sequence
AAGGAATCACAGATACTGTTGTATAGTTGTTGTATAGTTCCTCTAAAAGTTATTTAACCAAATAATTTTTATCAACCTGTAAAAGTATATGGACTTTttc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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