Basic Information
VIS ID
TVIS44017265
Fusion event
HTLV-1-LAYN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
111431773/111561048 (Hg38)
End
111431773/111561048 (Hg38)
Orient
+
Location type
UTR3
Target gene
LAYN
miRNAs that regulate target gene
hsa-mir-1303 ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-4781-3p ; hsa-mir-483-5p ; hsa-mir-3674 ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-10392/Upstream/47533; hsa-let-7a-2/Downstream/1888975;
Nearest TSS
ENST00000527297/Upstream/19496; ENST00000533868/Downstream/41343;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/19574, chr11-CpG: 127/Downstream/40951
Upstream sequence
AAGAGCAGGAAACAGAGTGTTAGTCTGTGTCTACAGCCCTTCCTCTGCATGTGGCCACAGGGGACCTTTTTTTGTTTCTCCTGACATCCAGACTTGGAAA
Downstream sequence
TATCTAACTACTTGCAAAACTAAAAATGAggccaggcgcagtggctgacgcctgtaatcccagaaccttgggagaccaagattggaggatagcttgagtt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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