Basic Information
VIS ID
TVIS44017270
Fusion event
HTLV-1-NXPE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
114394675/114523953 (Hg38)
End
114394675/114523953 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11G ; FRA11B
Target gene
NXPE1
miRNAs that regulate target gene
hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-296-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-10392/Upstream/1073865; hsa-let-7a-2/Downstream/4120047;
Nearest TSS
ENST00000527297/Upstream/75016; ENST00000389586/Downstream/6067;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/84089, chr11-CpG: 26/Downstream/437082
Upstream sequence
tcaggacttcTATACTGATACTACGTTCtgtatgagataggaaaccagtttgaatgctgtaagaaagaccaagataataatgacttaaaaataaaagatt
Downstream sequence
atttctgtctcacataacaggcctggagtgagaaggccagggctaatatgccattgcatggtgtcagggactcttgttccttctatgttgtggctatgac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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