Basic Information
VIS ID
TVIS44017281
Fusion event
HTLV-1-CEP164 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
117263278/117392562 (Hg38)
End
117263278/117392562 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA11G ; FRA11B
Target gene
CEP164
miRNAs that regulate target gene
hsa-mir-328-3p ; hsa-mir-378a-3p
Nearest miRNA
hsa-mir-10392/Upstream/3942474; hsa-let-7a-2/Downstream/1251438;
Nearest TSS
ENST00000527297/Upstream/7965; ENST00000532187/Downstream/16455;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/64328, chr11-CpG: 22/Downstream/89414
Upstream sequence
CACACTCCCCTGTGTGTGCGGGGGCCTCCTCAGGTGGTCTCCAGCCTCCAGAAGAAGATACAGGAAGCTCAACAGAAAGAGGAGGCCCAGCTGCAGAAGT
Downstream sequence
GCCTTGGGCAAGTGGAGCACAGAGTTCACCAGAAGTCTTATCACGTGGCTGGGTATGAGCACGAGGTGAGTGCTGCTCTGTCTTCCACAGTCGTGTGCGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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