Basic Information
VIS ID
TVIS44017287
Fusion event
HTLV-1-DKK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
11995418/11973871 (Hg38)
End
11995418/11973871 (Hg38)
Orient
+
Location type
Intronic
Target gene
DKK3
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-92b-3p ; hsa-mir-3679-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-2355-5p ; hsa-mir-942-5p ; hsa-mir-6793-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-642a-5p ; hsa-mir-4749-3p ; hsa-mir-6515-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6734-3p ; hsa-mir-877-3p ; hsa-mir-5088-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-6887-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-4690-5p ; hsa-mir-3120-3p ; hsa-mir-4684-5p ; hsa-mir-4799-5p ; hsa-mir-4775 ; hsa-mir-6781-3p ; hsa-mir-2682-3p ; hsa-mir-520f-5p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-590-3p ; hsa-mir-582-3p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-210/Upstream/190649; hsa-let-7a-2/Downstream/189812;
Nearest TSS
ENST00000527297/Upstream/5125; ENST00000531559/Downstream/6045;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/131400, chr11-CpG: 94/Downstream/34319
Nearest cancer related gene
DKK3(TSG, No orient, 0)
Upstream sequence
CAAAGGAGCCATTCAGAGTCTTTGATTTTCCAGTTTAGAGTTGATCAGAGGAGAGAGGCTCTGAGTGAGCAGAAGTCAAAACTTGGAGGAGGGAGAGGAC
Downstream sequence
AACAATGAGTCCCTGGAGGCTTTCCCAGAGTCTGTGTGGGGCCCGCAGAGGCACCGCTTCTTTGGGACCCTTCTGATGCTGCATCTCATTCCTCATACTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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