Basic Information
VIS ID
TVIS44017291
Fusion event
HTLV-1-UBASH3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
122550268/122679560 (Hg38)
End
122550268/122679560 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBASH3B
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-200a-3p ; hsa-mir-491-3p ; hsa-mir-192-3p ; hsa-mir-1227-3p ; hsa-mir-4275 ; hsa-mir-586 ; hsa-mir-3662 ; hsa-mir-455-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-486-5p ; hsa-mir-4797-5p
Nearest miRNA
hsa-let-7a-2/Upstream/527252; hsa-mir-3167/Downstream/701880;
Nearest TSS
ENST00000527297/Upstream/23835; ENST00000526386/Downstream/29702;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/22789, chr11-CpG: 51/Downstream/203118
Upstream sequence
taccaaccaggagcttgttagaaacatagaatctcagctctacctcaaacccactacgttagaatctccactttaataagatccttaggtgattggtatg
Downstream sequence
tacactgaagtctgggaCACCTTGATCTCTAGcaaggaccagcaaactctgtagagggccagagagtaaatatttcaggcttggccgaccatatggtctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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