Basic Information
VIS ID
TVIS44017310
Fusion event
HTLV-1-LDHC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
18435331/18413784 (Hg38)
End
18435331/18413784 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
LDHC
Nearest miRNA
hsa-mir-210/Upstream/25924; hsa-let-7a-2/Downstream/1161526;
Nearest TSS
ENST00000527297/Upstream/1066; ENST00000615355/Downstream/42040;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/17406, chr11-CpG: 39/Downstream/41967
Upstream sequence
tttcttgacctcgtgatccgcctgcctcagcctcccaaagtgctgggattacaggcatgagccaccacgcctggccTTAAGTAGGGACTTTTACTTCTTT
Downstream sequence
CCCTTACTGTTCGCTTTTGGAATCTGGCTATTGAAATCTGAATGAATACACTCCTtgtatatagttccgtactctgtcacatgtgacaaaaacccagttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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