Basic Information
VIS ID
TVIS44017322
Fusion event
HTLV-1-KCNQ1OT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
2649576/2628346 (Hg38)
End
2649576/2628346 (Hg38)
Orient
+
Location type
ncRNA_exonic
Target gene
KCNQ1OT1
Nearest miRNA
hsa-mir-210/Upstream/455208; hsa-let-7a-2/Downstream/1227716;
Nearest TSS
ENST00000527297/Upstream/166459; ENST00000526095/Downstream/71648;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/46107, chr11-CpG: 159/Downstream/70834
Upstream sequence
ctaacaaaaatgtataagggacaccttttctccacatcctcaccaacacttgctatcttttgactttttgataatagcgattctaacagttatgaggtga
Downstream sequence
tatctcagtgtggttttcatttgcatttccctgatgataagtgatgttaagcacctttttatatacctgttgaccatctgtatgtcttctttgaataaat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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