VISDB - VIS Detail

Basic Information

VIS ID

TVIS44017327

Fusion event

HTLV-1-CARS integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

29186194

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr11

Cytoband

p15.4

Reference genome

GRCh37/hg19

Start

3044718/3023488 (Hg38)

End

3044718/3023488 (Hg38)

Orient

-

Location type

Intronic

Target gene

CARS

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-652-3p ; hsa-mir-92a-3p ; hsa-mir-30a-5p

Nearest miRNA

hsa-mir-210/Upstream/850350; hsa-let-7a-2/Downstream/832574;

Nearest TSS

ENST00000527297/Upstream/13955; ENST00000630527/Downstream/5521;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/30537, chr11-CpG: 77/Downstream/33424

Upstream sequence

tacatacatacatacattcaaacacacacacaggatcttgctgtcagccaggctggagtgcaacggtgtaatcacagctcactacagcctcgacctccct

Downstream sequence

ggctcaagcaaccctcttacctcagccttctgagtaactgggactacaggtgcatgctaccacactcagctaatttttaaaatttttgtagagatgcggt

Reference

Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.