Basic Information
VIS ID
TVIS44017330
Fusion event
HTLV-1-OSBPL5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
3170679/3149449 (Hg38)
End
3170679/3149449 (Hg38)
Orient
-
Location type
Intronic
Target gene
OSBPL5
miRNAs that regulate target gene
hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-744-5p ; hsa-mir-1539 ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-449b-3p
Nearest miRNA
hsa-mir-210/Upstream/976311; hsa-let-7a-2/Downstream/706613;
Nearest TSS
ENST00000527297/Upstream/20120; ENST00000455154/Downstream/11944;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/28802, chr11-CpG: 42/Downstream/10895
Upstream sequence
CCCTATCTGGTGGCCAGGAAAGGGGCAAGATCTTGCAGTGTACTGGCCTCTGGTGAGGGAGGCAGTGAGTGCTGTGACTGTGGCTGACCCTCTTGCCAGC
Downstream sequence
ATCCTCCCTGTCCCCATCAACATGACCAGAGTGCTTGCCGCTCCATGAGCTTCCCCTGCCCATGTGTGCCTGTGGCAGGGGTGCCGCCCGCGCAGGCCGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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