Basic Information
VIS ID
TVIS44017334
Fusion event
HTLV-1-ABTB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
34263598/34242051 (Hg38)
End
34263598/34242051 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
ABTB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-5p
Nearest miRNA
hsa-mir-210/Upstream/5764503; hsa-let-7a-2/Downstream/699786;
Nearest TSS
ENST00000527297/Upstream/95331; ENST00000528104/Downstream/494;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/67342, chr11-CpG: 143/Downstream/114631
Upstream sequence
TCCACACATTGATTGAGCCTCCTGGCCCCTTGTTTGCTTCAACAAATGAAAGAAGCAAAATGCAGAAGCTGCGAGGAGATGGCTCGGGCCCTGCGTTGGA
Downstream sequence
AATCTCTCTCCATGGCCACTGCCCACCTCAACTGTGCTATGGAGTTCCCCTCACTTCTGGGGCCCACAACAACTGCACAGAAGAGTGGGCTTTTGCCTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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