Basic Information
VIS ID
TVIS44017337
Fusion event
HTLV-1-LDLRAD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
35966972/35945422 (Hg38)
End
35966972/35945422 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
LDLRAD3
miRNAs that regulate target gene
hsa-mir-744-5p
Nearest miRNA
hsa-mir-1343/Upstream/1003502; hsa-let-7a-2/Downstream/64676;
Nearest TSS
ENST00000527297/Upstream/1323; ENST00000529759/Downstream/164503;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/518, chr11-CpG: 122/Downstream/430981
Upstream sequence
TTGATGTCCCTGGTCCTGGGCATCCTCACAGCCCACTGGGCAGCCTTTCCTGCTCTCAGACCCATGACATCATCTCCACTCCTCTGATACCCCATTTAGA
Downstream sequence
TGCTTATGGGTTTGCTGGGCTTCCAGGGAGGGACTAGACCTCCTGGTGACTGCTGTGGATTTTTAACCAGGTCTGGGTGAGAGTGCCCTTAAATTAGTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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