Basic Information
VIS ID
TVIS44017339
Fusion event
HTLV-1-COMMD9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
36294831/36273281 (Hg38)
End
36294831/36273281 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA11E
Target gene
COMMD9
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-24-3p ; hsa-mir-423-3p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-891a-3p ; hsa-mir-4284 ; hsa-mir-564 ; hsa-mir-3194-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-2276-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-5693 ; hsa-mir-6890-3p ; hsa-mir-6796-3p ; hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-504-3p ; hsa-mir-6499-3p
Nearest miRNA
hsa-mir-1343/Upstream/263077; hsa-let-7a-2/Downstream/7286375;
Nearest TSS
ENST00000527297/Upstream/109982; ENST00000531269/Downstream/78;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/328377, chr11-CpG: 122/Downstream/103122
Upstream sequence
tggcttctgaccttggctgcctgactcctgacagcatattcttaatcTGTGGATTTACCTCCTCCATTCACTCCATACACAAACTAGCAGAGAAGCTGCC
Downstream sequence
AAAACAAAGCACTCCAAGAGCAGGCTGCAAGCTGTTGCCATGGAGATGATCTGGTGAGTGAAGGGGGAATCTTCACACATGGAGTCCCTGTGAGGCGTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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