Basic Information
VIS ID
TVIS44017391
Fusion event
HTLV-1-RAB6A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73469742/73758697 (Hg38)
End
73469742/73758697 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
RAB6A
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-186-5p ; hsa-mir-21-5p ; hsa-mir-324-5p ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-488-3p ; hsa-mir-4699-5p ; hsa-mir-382-5p ; hsa-mir-548an ; hsa-mir-195-3p
Nearest miRNA
hsa-mir-10392/Upstream/975105; hsa-let-7a-2/Downstream/640540;
Nearest TSS
ENST00000527297/Upstream/36348; ENST00000540547/Downstream/1398;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/97110, chr11-CpG: 112/Downstream/1533
Upstream sequence
TAGAACATACACAAATACTCAAGAAATTCAAAGGAAACCTGAAGATACTTAGGAAGTTAAGCACTCCATTCATGCTAAAACCTTTTTAGGCAGGAAGATG
Downstream sequence
AATAGGTTTTTTCATGCAAACTAAATAGCTGTGCATCACAACATAAGGAAGGCAATAATATCCTTAGAATGCACAATAAGCACTTTGGATCCTTTTTATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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