Basic Information
VIS ID
TVIS44017394
Fusion event
HTLV-1-ARRB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
74976401/75265357 (Hg38)
End
74976401/75265357 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA11H
Target gene
ARRB1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-525-3p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6126 ; hsa-mir-491-5p ; hsa-mir-92a-2-5p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-6804-5p ; hsa-mir-3913-3p ; hsa-mir-605-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-4779 ; hsa-mir-574-5p ; hsa-mir-568 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-642a-5p ; hsa-mir-3140-3p ; hsa-mir-6859-3p ; hsa-mir-4469 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6887-3p ; hsa-mir-4640-3p
Nearest miRNA
hsa-mir-10392/Upstream/545020; hsa-let-7a-2/Downstream/69735;
Nearest TSS
ENST00000527297/Upstream/1068; ENST00000534555/Downstream/9581;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/22911, chr11-CpG: 97/Downstream/85823
Upstream sequence
GACTCTCCTCTCCCCGCCCCCTGCCCCCATCTCTGAGCGCCCCCCTTCGGGAACCCTCCTCAGGAGCTTCAGCTCACTCTGCTGGGGGCTGGTGCTTGCT
Downstream sequence
GAAGACCCCCTCCCTCCCTCCCTCTGCTTTTCTCTCTGTGCATATCTCTAGACAGGGCCATGCACTTGAAATACAAGGTAGCTAAGATGTCACAGCCTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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