Basic Information
VIS ID
TVIS44017400
Fusion event
HTLV-1-TENM4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
78520480/78809435 (Hg38)
End
78520480/78809435 (Hg38)
Orient
+
Location type
Intronic
Target gene
TENM4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-193b-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-100-3p ; hsa-mir-3121-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-642a-5p ; hsa-mir-4290 ; hsa-mir-1236-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6736-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6826-3p ; hsa-mir-3925-3p ; hsa-mir-3667-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-622 ; hsa-mir-532-5p
Nearest miRNA
hsa-mir-10392/Upstream/3474249; hsa-let-7a-2/Downstream/592587;
Nearest TSS
ENST00000527297/Upstream/4024; ENST00000525952/Downstream/94451;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/133056, chr11-CpG: 38/Downstream/93725
Upstream sequence
TTAAGGAAGACTGCATCTCAGGAGGGAAGGCAGCTCCCAGAAATCTAGGCTGAACTGGCTGAGGTTCCTGCTGGGGCTGGGCAGACACTGTCCTTGTGCT
Downstream sequence
CTACTGATCCTATAGGGCCAGTATCTATGCCACAATGATGCTCTGCCAAAGAGGTGGTAGGTAGACTCTGCCTCTGCCTTTGCATCCTGGAGCCTCTGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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