Basic Information
VIS ID
TVIS44017419
Fusion event
HTLV-1-AP2A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
936499/936499 (Hg38)
End
936499/936499 (Hg38)
Orient
-
Location type
Intronic
Target gene
AP2A2
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-92b-3p ; hsa-mir-331-3p ; hsa-mir-93-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-210/Upstream/368301; hsa-let-7a-2/Downstream/320106;
Nearest TSS
ENST00000527297/Upstream/2938; ENST00000530801/Downstream/4236;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/10416, chr11-CpG: 30/Downstream/7238
Upstream sequence
ttagttatttattgacagggtctcattcgcattgcccaggctggagtgcaatgttgcaatcatagcttacttcagccttgacttcctgggctcaggtgat
Downstream sequence
cctcttgcctcagcttcttgagtggctgggaccacagccacacctggctaatttttaaaaaacttttttgtagaaatggggtcttgctttgtagcccagg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate