Basic Information
VIS ID
TVIS44017441
Fusion event
HTLV-1-UNG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
109540553/109102748 (Hg38)
End
109540553/109102748 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
UNG
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-34c-5p ; hsa-mir-199a-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-24-3p ; hsa-mir-129-2-3p ; hsa-mir-125b-5p ; hsa-mir-28-5p ; hsa-mir-1911-5p ; hsa-mir-3148 ; hsa-mir-204-3p ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-4515 ; hsa-mir-4646-5p ; hsa-mir-4668-5p ; hsa-mir-5011-5p ; hsa-mir-3169 ; hsa-mir-3682-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-6076 ; hsa-mir-6797-3p ; hsa-mir-20a-3p ; hsa-mir-4686
Nearest miRNA
hsa-let-7i/Upstream/265742; hsa-mir-1178/Downstream/730600;
Nearest TSS
ENST00000382841/Upstream/4597; ENST00000539864/Downstream/13847;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/4122, chr12-CpG: 21/Downstream/8346
Upstream sequence
CTTTGGCAGAGTCACCTGTTAGAAGGAGGACTGGCAGTGTTGATCTCATTAATCGGCGCCATATGTGCCAGTGTCCCTTCCAAGGGCTGGCTGTAACTTC
Downstream sequence
TAACCTTTTCACATATGTCTTAGACGTTACTGAGCTTTCAAAATTATGCTTAAGATTCTGTTTTTTGTTTTTCTTGTGGCTTGCTTTCAGTTTGGAGAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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