Basic Information
VIS ID
TVIS44017444
Fusion event
HTLV-1-PHETA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
111801292/111363488 (Hg38)
End
111801292/111363488 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
PHETA1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-1972 ; hsa-mir-214-3p ; hsa-mir-4267 ; hsa-mir-4269 ; hsa-mir-4514 ; hsa-mir-4692 ; hsa-mir-4755-3p ; hsa-mir-5582-5p ; hsa-mir-6715b-5p ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-940 ; hsa-mir-1207-3p ; hsa-mir-138-5p ; hsa-mir-2861 ; hsa-mir-3065-3p ; hsa-mir-3667-3p ; hsa-mir-383-3p ; hsa-mir-384 ; hsa-mir-4297 ; hsa-mir-4456 ; hsa-mir-4757-5p ; hsa-mir-5571-3p ; hsa-mir-5581-5p ; hsa-mir-5702 ; hsa-mir-6744-3p ; hsa-mir-6765-3p ; hsa-mir-6804-3p ; hsa-mir-6878-3p ; hsa-mir-7851-3p ; hsa-mir-7975 ; hsa-mir-937-5p ; hsa-mir-939-3p
Nearest miRNA
hsa-let-7i/Upstream/59279; hsa-mir-1178/Downstream/436346;
Nearest TSS
ENST00000382841/Upstream/149187; ENST00000548846/Downstream/224;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/48, chr12-CpG: 50/Downstream/5267
Upstream sequence
GGTGGCGTAGAAGGCCAGGCTGCGCTCGTTCAGCTTCATGGTGGCAATCGCGGGGCCTGGAGGGGAGCCTGGGGCCTGGACCCCATAGAAGGGCTGTTAT
Downstream sequence
GCACAAGGCCACTGACGCTAGGTCACCCAGTGCCCCAaggggaccttgcagccactctacatccccgtttcacagatgaggaaactgacgctcatagggt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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