Basic Information
VIS ID
TVIS44017449
Fusion event
HTLV-1-RBM19 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
114292604/113854799 (Hg38)
End
114292604/113854799 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12D
Target gene
RBM19
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-98-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7i/Upstream/563191; hsa-mir-1178/Downstream/2293761;
Nearest TSS
ENST00000382841/Upstream/36620; ENST00000550206/Downstream/4105;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/262852, chr12-CpG: 34/Downstream/111398
Upstream sequence
GCAGATGGTCAGGACCCACCCCCGGTTCACTGGAGCAGCTCAGTAACAGACCGGGGTCTGGGCTTCCCATCAATTCATAGGGCTCCACGGTGGCTTCAGT
Downstream sequence
GCTGGAGTTTAGCAAATGCTCAGCGAGACTGGGGAGGGAGACTGGATGCAAATCTCCCACCCGATGCTGGAGCTGCCACAGGTTGGGGTGGGGCAGTGCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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