Basic Information
VIS ID
TVIS44017460
Fusion event
HTLV-1-TMEM132C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
129135485/128650940 (Hg38)
End
129135485/128650940 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
TMEM132C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7156-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-1184 ; hsa-mir-1976 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-141-5p
Nearest miRNA
hsa-let-7i/Upstream/356762; hsa-mir-6763/Downstream/3931057;
Nearest TSS
ENST00000382841/Upstream/383537; ENST00000611714/Downstream/150761;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/235420, chr12-CpG: 21/Downstream/54250
Upstream sequence
ATGTCCCATTTACATGGATGCAAATGAGGTAAGGCTCAAATTCCACCAACTGGAGTGGTGTGGGCTCCAACGAATCAGAACAGACCAGAGTCATAACACT
Downstream sequence
GACCAATCAGAAGGGGGTCAGAGGGTCCACGTAGACCACAGAGCAGCAGCATGGGTATAAATCTCCACCCCTCAGATGGGGACTGCAGATTCAAACCATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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