Basic Information
VIS ID
TVIS44017465
Fusion event
HTLV-1-FBRSL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
133112383/132535797 (Hg38)
End
133112383/132535797 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
FBRSL1
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-147a ; hsa-mir-2113 ; hsa-mir-34a-3p ; hsa-mir-4519 ; hsa-mir-4668-3p ; hsa-mir-5010-3p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-8062
Nearest miRNA
hsa-let-7i/Upstream/4241619; hsa-mir-6763/Downstream/46200;
Nearest TSS
ENST00000382841/Upstream/28767; ENST00000543360/Downstream/24250;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/9779, chr12-CpG: 33/Downstream/13276
Upstream sequence
AGAGACCCAGAGGGGAGGCTCGCAGGGCCAGCGGTTAGGAGTCCTGCATGTGTGCACGTGTACATGACAgtgtgagtgcacgtgtgtccatgatggtgtg
Downstream sequence
cgtgagtgcacgtgtgtccatgatggtgtgagtgcacgtgtccatggtgtgtgagtgcacgtgtgtccatgatggtgtgagtgcacgtgtccatggtgtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate