Basic Information
VIS ID
TVIS44017468
Fusion event
HTLV-1-STRAP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
16045397/15892463 (Hg38)
End
16045397/15892463 (Hg38)
Orient
-
Location type
Intronic
Target gene
STRAP
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-16-5p ; hsa-mir-374b-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2976545; hsa-let-7i/Downstream/1780836;
Nearest TSS
ENST00000382841/Upstream/10068; ENST00000536737/Downstream/2991;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/9561, chr12-CpG: 54/Downstream/18683
Upstream sequence
TATAGGTGTCTTCCCCAGTCTACATGtttattttataatattttaataatttCCCTCACCATATATATACTTAGCTACCAAAACATGACAAACATAATTT
Downstream sequence
TGTTTTATTATATATTTGGTATCTTTCAGATTTTATTATGTGGACATTTATGTAGTCATAAATCTATAAAATTTTAAAGAGTAATAAGAGAGTCAGAACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate