Basic Information
VIS ID
TVIS44017490
Fusion event
HTLV-1-CRACR2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.32
Reference genome
GRCh37/hg19
Start
3804910/3695744 (Hg38)
End
3804910/3695744 (Hg38)
Orient
-
Location type
Intronic
Target gene
CRACR2A
Nearest miRNA
hsa-mir-3649/Upstream/2035364; hsa-let-7i/Downstream/3267955;
Nearest TSS
ENST00000382841/Upstream/22220; ENST00000637958/Downstream/56774;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/201902, chr12-CpG: 59/Downstream/57158
Upstream sequence
CCAACTTTGGTATATTCTGAAAAACTAGACTTAAAGAAAGAGAGCCTAGCCATTGTGCTTCCTCCAACAGCACAGGGATGCGTCCCTTCAAAAACTACTC
Downstream sequence
TGATGGAGTGAGTGACACAAAGACTCAGGGGAAAAGAGCTGCTTTCAAAGTACTCTAGTGAAGTCTGTATTTTATTCACCCATGTTCAAGTGAAATCTTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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