Basic Information
VIS ID
TVIS44017491
Fusion event
HTLV-1-PARP11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.32
Reference genome
GRCh37/hg19
Start
3925857/3816691 (Hg38)
End
3925857/3816691 (Hg38)
Orient
+
Location type
Intronic
Target gene
PARP11
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-122-5p ; hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-mir-1273e ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-6799-5p ; hsa-mir-31-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6134 ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-1247-3p ; hsa-mir-3123 ; hsa-mir-302f ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-4779 ; hsa-mir-374a-3p ; hsa-mir-421 ; hsa-mir-4709-5p ; hsa-mir-136-3p ; hsa-mir-212-3p ; hsa-mir-132-3p
Nearest miRNA
hsa-mir-3649/Upstream/2156311; hsa-let-7i/Downstream/3147008;
Nearest TSS
ENST00000382841/Upstream/51872; ENST00000545163/Downstream/5283;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/63251, chr12-CpG: 80/Downstream/22065
Upstream sequence
attagtgaatccatactggttTTCTCAAAGAAACATTAGTATCATACATAATGCCAGGCTTCATGGTCTGTAATGTCAAACTTGTCAATGTTGTGCTTCA
Downstream sequence
TGATCTGCAATGACTAGAATCCACTCTAAGgaaattctgtctctactaaaagatacaaaaattagctgggtgtggtggcacacacctgtaatcccagcta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate