Basic Information
VIS ID
TVIS44017493
Fusion event
HTLV-1-TMEM117 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
44226475/43832672 (Hg38)
End
44226475/43832672 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM117
miRNAs that regulate target gene
hsa-mir-5010-3p ; hsa-mir-192-3p ; hsa-mir-365b-5p ; hsa-mir-8052 ; hsa-mir-365a-5p ; hsa-mir-3199 ; hsa-mir-95-5p ; hsa-mir-4477a ; hsa-mir-2116-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-302a-5p ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-5584-3p ; hsa-mir-6874-3p ; hsa-mir-148b-5p ; hsa-mir-3168 ; hsa-mir-5571-5p ; hsa-mir-8066
Nearest miRNA
hsa-mir-1244-3/Upstream/1508813; hsa-let-7i/Downstream/3355140;
Nearest TSS
ENST00000382841/Upstream/26297; ENST00000546387/Downstream/3295;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/26070, chr12-CpG: 75/Downstream/3130
Nearby gene
TMEM117(+3189) ;
Upstream sequence
TTTGTATAACTTTATAGCGAGTAAGCAGTGGAGCCAGAATTTATACCAATATTCATTATATCAGGTCTCCTAACCATAAAAGCCACATCTCTTTCCTCTT
Downstream sequence
ATATGGGGAGGAAGTATTATGTAAGATGagaggttaaaacgtgggctgacaagccacattgcctggtttctgatccttactctaccactatggctacttg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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