Basic Information
VIS ID
TVIS44017500
Fusion event
HTLV-1-ARF3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
49328372/48934589 (Hg38)
End
49328372/48934589 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
ARF3
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-320a ; hsa-mir-125b-5p ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-6834-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-34c-3p ; hsa-mir-6760-5p ; hsa-mir-5195-5p ; hsa-mir-582-3p ; hsa-mir-183-5p ; hsa-mir-377-3p ; hsa-mir-3941 ; hsa-mir-342-3p ; hsa-mir-4650-5p ; hsa-mir-6768-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4789-5p ; hsa-mir-4477a ; hsa-mir-4424 ; hsa-mir-6770-5p ; hsa-mir-3976 ; hsa-mir-3123 ; hsa-mir-3925-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/162552; hsa-let-7i/Downstream/1299553;
Nearest TSS
ENST00000382841/Upstream/8115; ENST00000613114/Downstream/5074;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/9082, chr12-CpG: 52/Downstream/22467
Nearby gene
ARF3(-1620) ;
Upstream sequence
CCCCTCAAAAGAACTGGAAGGCTTCAGCAACTGCCACAAGAGGGCTCCCCTCTACTTCCTTCCTGGCATTCTAAATTGAGTACTAAGGGACAGATGGGAA
Downstream sequence
TAGGTCATCCTCTTCCCCAAGTTGTTCAGGGGTCCAAAGACCCCCCAGTGGCCCACCATTCAGCTAAAGTCCTCTCCCTTATCATTATGAGAGGTTGTAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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