VISDB - VIS Detail

Basic Information

VIS ID

TVIS44017501

Fusion event

HTLV-1-TUBA1A integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

29186194

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr12

Cytoband

q13.12

Reference genome

GRCh37/hg19

Start

49578972/49185189 (Hg38)

End

49578972/49185189 (Hg38)

Orient

-

Location type

Exonic

Fragile sites / regions

FRA12A

Target gene

TUBA1A

miRNAs that regulate target gene

hsa-mir-30a-3p ; hsa-mir-124-3p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-324-5p ; hsa-mir-10a-5p ; hsa-mir-16-5p ; hsa-mir-412-3p

Nearest miRNA

hsa-mir-1244-3/Upstream/413152; hsa-let-7i/Downstream/1048953;

Nearest TSS

ENST00000382841/Upstream/53479; ENST00000549554/Downstream/1675;

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/53480, chr12-CpG: 67/Downstream/3124

Upstream sequence

CCATGTCCTCACGGGCCTCTGAAAACTCACCTTCCTCCATCCCCTCCCCAACGTACCAGTGAACAAAGGCACGTTTGGCATACATCAGGTCAAACTTGTG

Downstream sequence

GTCCAGGCGAGCCCAGGCCTCAGCAATGGCTGTGGTGTTGCTCAGCATGCACACAGCTCTCTGTACCTTGGCCAGGTCTCCACCAGGCACCACAGTGGGA

Reference

Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.