Basic Information
VIS ID
TVIS44017504
Fusion event
HTLV-1-KRT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
53183753/52789969 (Hg38)
End
53183753/52789969 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA12A
Target gene
KRT3
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2555757; hsa-let-7i/Downstream/108920;
Nearest TSS
ENST00000382841/Upstream/12624; ENST00000548015/Downstream/6148;
Nearest CpG islands
chr12-CpG: 40/Target, None/Upstream, None/Downstream
Upstream sequence
CTCGTGACTGGGCTTGGCCGGGGATCTGGAAGGAGGAGCAAGAGGCCACAAGCCTTCCAGCGCAGAGCCGCGTTCTTGGGGAGCATGGGGTGGCGCTGGG
Downstream sequence
GGTGTTGCCAATATGGGGGCGTGGGGAGCGGAGGGGAGGCGCTGGAGTGGCTGCGATGCTGATGCGTGCTCTTTATCTGGAGTAGCGctgggaggactgg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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