Basic Information
VIS ID
TVIS44017509
Fusion event
HTLV-1-NEMP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57452316/57058533 (Hg38)
End
57452316/57058533 (Hg38)
Orient
-
Location type
UTR3
Target gene
NEMP1
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-192-5p ; hsa-mir-24-3p ; hsa-let-7d-5p ; hsa-mir-93-3p ; hsa-mir-155-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/2721219; hsa-let-7i/Downstream/135971;
Nearest TSS
ENST00000382841/Upstream/7335; ENST00000555857/Downstream/20230;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/51845, chr12-CpG: 29/Downstream/19958
Upstream sequence
AGACTTTTCCAGGGTATAAGGGTGAAGACCACAAAGAAAAAGAACCAAGTAAATGACAGACACTTGAGAATTTGCTTCCTCACAGATGACATTGCTGGTT
Downstream sequence
TATAAGGGGTACTTTGCAATGGCAAAAGAATCTGAAACTAATGCTACTGCAATAACAGGCAGCATACATCTCAGGTCAGAAACGCAATCATAAATAAGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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