Basic Information
VIS ID
TVIS44017510
Fusion event
HTLV-1-AVIL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
58195105/57801322 (Hg38)
End
58195105/57801322 (Hg38)
Orient
-
Location type
Intronic
Target gene
AVIL
miRNAs that regulate target gene
hsa-mir-9-5p
Nearest miRNA
hsa-mir-1228/Upstream/52640; hsa-let-7i/Downstream/23287;
Nearest TSS
ENST00000382841/Upstream/669; ENST00000602802/Downstream/95;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/28364, chr12-CpG: 151/Downstream/44157
Upstream sequence
GAGAGAGAAAACACAGGATGAGGTCTTTCTTATAGGGGAGGGACATCTTAGGTCTGGTCTGTGTCTTCAGGAAAAGCAAAAGAGCCAGGGAGTCAGAAGA
Downstream sequence
CATTTCAAGGATAAGTAAAAATGAAAATCCCCCCTTTTGGGTCCATGCAGGCTTGAAAGGTGCTTAAACATAACGCACATTCTTTGATGGTAACCCCTCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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