Basic Information
VIS ID
TVIS44017519
Fusion event
HTLV-1-NCAPD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
6635698/6526532 (Hg38)
End
6635698/6526532 (Hg38)
Orient
-
Location type
Exonic
Target gene
NCAPD2
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-155-5p ; hsa-mir-16-5p ; hsa-mir-1303 ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-222-3p ; hsa-let-7b-5p ; hsa-mir-3620-3p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-371b-3p ; hsa-mir-449b-3p ; hsa-mir-4438 ; hsa-mir-8070 ; hsa-mir-106a-3p ; hsa-mir-3650 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6741-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-320e ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-3649/Upstream/4866152; hsa-let-7i/Downstream/437167;
Nearest TSS
ENST00000382841/Upstream/3332; ENST00000535804/Downstream/2015;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/32392, chr12-CpG: 123/Downstream/7563
Upstream sequence
CCTCCTCCTCTGCAGGCTTTGTCCACCCAGACCCACTCTGGATCCCATTCAAAGAGGTGGCAGTGACCCTCATTTACCAACTGGCAGAGGGCCCCGAAGT
Downstream sequence
GATCTGTGCCCAGATATTGCAGGGCTGTGCAAAACAGGCCCTGGAGAAGCTAGAAGAGAAGAGAACCAGTCAGGAGGACCCGAGTAAGTGGGCAGGGGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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