Basic Information
VIS ID
TVIS44017537
Fusion event
HTLV-1-CSRP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
77256930/76863150 (Hg38)
End
77256930/76863150 (Hg38)
Orient
+
Location type
Intronic
Target gene
CSRP2
miRNAs that regulate target gene
hsa-mir-3591-5p ; hsa-mir-513a-5p ; hsa-mir-142-3p ; hsa-mir-155-5p ; hsa-mir-4451 ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-4650-3p ; hsa-mir-138-5p ; hsa-mir-6131 ; hsa-mir-133a-5p ; hsa-mir-7157-3p ; hsa-mir-6737-3p ; hsa-mir-5008-3p ; hsa-mir-6889-3p ; hsa-mir-4255 ; hsa-mir-1244 ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-3681-3p ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-3129-5p ; hsa-mir-199a-3p ; hsa-mir-199b-3p
Nearest miRNA
hsa-let-7i/Upstream/7278327; hsa-mir-1178/Downstream/2556107;
Nearest TSS
ENST00000382841/Upstream/14912; ENST00000552426/Downstream/1804;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/98525, chr12-CpG: 68/Downstream/15647
Upstream sequence
ATCAGAGTCCCATTTTATTTGCTTAGTTTCAACTAAAAATCTGGAGACTGCCAGGTTCCTGTTCAGCAAGCGGCACTAACTGTCGCAACTCATTTCTGAA
Downstream sequence
GGTAACCAACGGTCTCCCAACTCACCTCTCTGGTTTGATGCCCAGCCTCTCGCCACGGTCCATGTTAAGCGTGCCAGCGCCCTGGCCATAACCGTAGCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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