Basic Information
VIS ID
TVIS44017541
Fusion event
HTLV-1-MGAT4C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
86514253/86120475 (Hg38)
End
86514253/86120475 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
MGAT4C
miRNAs that regulate target gene
hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-5584-5p ; hsa-mir-607 ; hsa-mir-1277-5p ; hsa-mir-496 ; hsa-mir-656-3p ; hsa-mir-410-3p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4666a-5p ; hsa-mir-5011-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-4789-3p ; hsa-mir-4719 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-4797-5p ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-3614-3p ; hsa-mir-1287-3p
Nearest miRNA
hsa-let-7i/Upstream/4962014; hsa-mir-1178/Downstream/624593;
Nearest TSS
ENST00000382841/Upstream/70750; ENST00000551280/Downstream/135792;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/839553, chr12-CpG: 52/Downstream/1914853
Upstream sequence
gctttgaagagagtagtggttctcccagcacgcagcttgagatctgagaacggacagactgcctcctcaagtgggtccctgacccctgagtagtctaact
Downstream sequence
gggagacacctcccagtaggggctgactgacacctcatacagccaggtgcccctctgagacgaagcttccagaggaagaatcaggcagcaacatttgccg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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