Basic Information
VIS ID
TVIS44017544
Fusion event
HTLV-1-TMCC3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
95009089/94615313 (Hg38)
End
95009089/94615313 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMCC3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-mir-6864-5p ; hsa-mir-6126 ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-4635 ; hsa-mir-4511 ; hsa-mir-3133 ; hsa-mir-548x-3p ; hsa-mir-5582-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-let-7i/Upstream/43961; hsa-mir-1178/Downstream/219085;
Nearest TSS
ENST00000382841/Upstream/118871; ENST00000551792/Downstream/748;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/154782, chr12-CpG: 90/Downstream/34462
Upstream sequence
ACACAGATTTCCTGTGAGATCAAAGGCTCCCCCAGGCAGAAATCACATGAACCTGAGCCTTCACCACCCTATGGGGAATGAATCCCACACTATGGGGTGT
Downstream sequence
CCAAGCATGGTCCGAGGAGGCCCAGTTCAGACGCACTCTCCATTTCCCCCATGGCTGCTTCCTCTCCCACAGCTCGAGGCAGCCACCACACCCTTCTTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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